ELEVATED INFLAMMATORY RESPONSES AND TARGETED THERAPEUTIC INTERVENTION IN A PRECLINICAL MOUSE MODEL OF ATAXIA-TELANGIECTASIA LUNG DISEASE

Elevated inflammatory responses and targeted therapeutic intervention in a preclinical mouse model of ataxia-telangiectasia lung disease

Abstract Ataxia-telangiectasia (A-T) is an autosomal recessive, multisystem disorder characterized by cerebellar degeneration, cancer predisposition, and immune system defects.A major cause of mortality in A-T patients is severe pulmonary disease; however, the underlying causes of the lung complications are poorly understood, and there are currentl

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